Frequently Asked Questions
How do I order from Stemnovate?
Products can be ordered directly from our website. Customers will be required to registered in order to checkout their purchases. Customers who have ordered from us previously will have access to a list of their previous purchases to allow them to quickly & easily place repeat orders if required.
Alternatively, please enquire HERE and we will be happy to discuss your requirements and provide you with a personalized quotation.
I have specialist requirements for a proposed R&D project in my lab, who should I talk to?
Please enquire HERE and we will be happy to discuss your requirements and provide you with a personalized quotation.
What types of cells can you provide?
Stemnovate can provide primary cell lines, fibroblasts, iPSCs and differentiated iPSCs from both human and animal sources.
Please enquire HERE for more details
Can we buy either frozen or live cells?
Yes, all of our cells be provided as either frozen vials or cultured living cells. Frozen cells can be shipped next day. Please allow 1-2 weeks for the culture and shipping of live cells. Cultured cells are provided with a small amount of conditioned media. We also keep a stock of the customer’s chosen cells cultured in-house for a short period following shipping to allow for any issues around shipping or culturing on receipt by the customer.
What do your customers use Stemnovate fibroblasts for?
Stemnovate’s Human Primary Dermal Fibroblasts have many applications, for example:
- In the assay of cell-cell interaction, adhesion, PCR, laminin, and fibronectin production.
- Studying fibroblasts growth factor response.
- In immunofluorescent flow cytometry.
- Generating cell derivatives for desired research applications.
- Ideal for 2D and 3D cultures, microfluidic devices, co-cultures, tissue engineering, and skin models
Human Dermal Fibroblasts (HDFs) have been responsible for producing the extracellular matrix forming the connective tissue of the skin and play a crucial role during wound healing. For instance, they play an important role in the progression of inflammation by secreting various factors that define the tissue microenvironment and modulate immune cell functions.
HDFs provide an excellent model system to study many aspects of cell physiology. For instance, they are remarkable for their utilization in dozens of research publications related to skin biology and reprogramming/induced pluripotency studies.
Dr. Shinya Yamanaka was awarded the Nobel Prize in 2012 (Takanashi, 2007; 2009) for using Human Dermal Fibroblasts in order to create induced pluripotent stem cells (iPSC) by using Oct3/4, Sox2, Klf4, and c-Myc.
What are induced stem cells (iPSCs)?
Stemnovate’s Induced pluripotent stem cells (iPSCs) are formed by reprogramming somatic cells such as skin (fibroblast, keratinocytes) or blood (PBMNCs, peripheral blood mononuclear cells).
What are iPSCs used for?
iPSCs represent a unique and ethical tool for modelling disease and organ toxicity, with enormous potential for drug discovery and cellular therapies.
What types of cells can iPSCs be differentiated into?
Stemnovate IPSC lines are capable of differentiating into any organ cells. For instance, functional liver cells (Hepatocytes), heart cells (Cardiomyocytes showing key cardiac markers and beating behaviour), and sensory neurons (showing neuronal marker expression and action potential generation on microelectrode arrays). The non-integrating method Stemnovate uses results in stable IPS line generation with high efficiency and reproducibility compared to other viral reprogramming methods. The ability to expand pluripotent cells in vitro and subject them to direct differentiation to produce specific cell types is crucial to developing cell-based therapies to replace or restore tissue.
Please enquire HERE for more details
Are Stemnovate cells tested for mycoplasma before they are shipped to customers?
Yes, cells are tested for HIV-1, HIV-2, HepA, HepB, HepC and mycoplasma, and are also shown to be negative for microbiological growth before shipping to customers.
Are Stemnovate compliant?
Stemnovate holds a commercial license from IPS Academia Japan for which Prof. Yamanaka and Prof Gurdon received the Nobel prize in 2012 for reprogramming technology.
Stemnovate also holds a Human Tissue Authority license (HTA) which permits us to ethically source cells under consent for commercial use.