HOW WE SUPPORT Pharma
According to the FDA, most medical treatments are designed for the “average patient” as a one-size-fits-all-approach, which may be successful for some patients but not for others. The human population shows huge variability to metabolize drugs as the enzymes involved in the process, the cytochrome P450 (CYP-P450) are encoded by 50 or more genes with a range of polymorphism, resulting in either increased or decreased activity. Stemnovate through a compliant liver platform provides research support for studying genetic difference in the drug transporters, intracellular receptors and the genetically inherited traits that can be a key to new drug development.
INNOVATIVE CUSTOM SOLUTIONS
Stemnovate offers high-value service contracts with the Pharmaceutical industry to create innovative custom solutions for safety evaluation of drugs candidates in all stages of the drug discovery and development process. We bring together multi-disciplinary areas of microengineering, microfluidics, patented sensor technology, cellular reprogramming and hepatocyte differentiation to create biomimetic liver systems for hepatotoxicity testing and safety screening assays.
stemnovate
TARGETED DRUG DEVELOPMENT

Stemnovate’s innovative Liver on chip technology takes into account variants in patient’s genetic that enable precision, carefully targeted drug development from the early stages of the process – resulting in safer and more cost-effective drug discovery.

Our platforms facilitates in-depth genomic, transcriptomic and bioinformatic analysis on iPS derived hepatocytes (HLCs) complementing cell line studies to determine the zygosity, cytochrome P450 (CYPs) expression and key pluripotency, hepatic transcripts and membrane transporters within a given population groups complimenting the traditional cell based assays.

FDA is already evaluating ‘on the chip technologies’ for effectiveness for drug discovery , microbiology and toxicology.

Products

Induced Pluripotent stem cell lines

Human & Multispecies Primary cells

Cell culture & analysis package

Services

Cell Reprogramming

Cell Differentiation

Application Development

Data

Pharmacogenomic Data 

Single Nucleotide Polymorphism

Transcriptomics

Pharmacokinetic/Pharmacodynamic Data

Device

Microphysiological systems

Microfluidic design, prototyping and manufacturing

Biosensing and Automation

Our clients say

You are doing some amazing and important work at Stemnovate, we are happy to be associated with your project.

Volunteer
Volunteer for blood donation for liver research

Thank you for your presentations, they were really great and stimulating. I am very happy we met and that we could get the cells in culture!

Academic Institution
University of Bern

Pharma CASE STUDIES

Partnering for SciSpacE Microgravity Application Promotion Programme

Stemnovate has partnered with multinational collaborators on a project coordinated by MEDES Institute of space medicine and physiology. 

25.10.2019
Partnering for advanced engineering and measurement standards

Stemnovate has partnered with National Physical Laboratory for advancing the biosensing technology and exploring the novel technologies for imaging of complex cellular models.

25.10.2019