OUR PLATFORM
Stemnovate has been awarded grant awards and co funding from prestigious organisations such as Innovate UK, for its innovative platform. The funding for project’ Liver on chip’ which has been covered by Cambridge Independent, Business Weekly and PWC is supporting technology advancement for a better and faster liver toxicity testing system. Stemnovate has been awarded European Regional Development Fund grant to support the growth plan implementation. Innovation Bridge is an economic development project that provides support to help business innovate and grow through access to specialist university expertise and grants.

HOW IT WORKS

How it works
Multiorgan solution

In vitro Absorption, distribution, metabolism and excretion studies can be conducted on tissues showing multicellular interactions in microphysiological systems.

Computational modelling & Big Data

The multiparametric data obtained from cell studies, assays, protein and gene expression and imaging is used for data analysis and predictive modelling of drug response.

Biosensing

The quantitative data is obtained through biosensors for microenvironment changes and physiological parameter analysis.

Drug Interaction studies

Cytochrome P450 studies are complimented with metabolism assays, expression profiling and transcriptomic analysis. A comprehensive data to understand the mechanistic of action or toxicity.

Cell based assays

In-depth studies for cell proliferation, apoptosis, receptors & transporters.

3D printing prototyping manufacturing

Microfluidic device development involves CAD design, 3D printing, prototyping following by application optimisation and manufacturing.

Pharmacogenetics

Pharmacogenetics allows the study of the genetic variation due to ethnicity and gender that affects their response or adverse reaction to
medicines or xenobiotics.
Stemnovate has diverse bank of IPS lines that represent the human variability for pharmacogenetics studies.

Reduces Animal Testing Veterinary Research and Development

Our multispecies cellular models allow in vitro studies for mechanism of action, transporters and signalling pathways. This reduced animal testing while the models benefit veterinary drug development and disease modelling.

Drug metabolism Cytochrome P450 studies

Cytochromes P450 (CYPs) are the main enzymes involved in drug metabolism. These show huge expression variability among humans. We study CYP inhibition, induction, expression and polymorphism.

Multicellular Modelling Tissue engineering

Tissue consists of specialised cells functioning while uniquely organised. We simulate this organisation for microphysiological studies. Eg, Liver tissue consists of hepatocytes, stellate and Kupffer cells.

Multiorgan solution

In vitro Absorption, distribution, metabolism and excretion studies can be conducted on tissues showing multicellular interactions in microphysiological systems.

Computational modelling & Big Data

The multiparametric data obtained from cell studies, assays, protein and gene expression and imaging is used for data analysis and predictive modelling of drug response.

Biosensing

The quantitative data is obtained through biosensors for microenvironment changes and physiological parameter analysis.

Drug Interaction studies

Cytochrome P450 studies are complimented with metabolism assays, expression profiling and transcriptomic analysis. A comprehensive data to understand the mechanistic of action or toxicity.

Cell based assays

In-depth studies for cell proliferation, apoptosis, receptors & transporters.

3D printing prototyping manufacturing

Microfluidic device development involves CAD design, 3D printing, prototyping following by application optimisation and manufacturing.

Pharmacogenetics

Pharmacogenetics allows the study of the genetic variation due to ethnicity and gender that affects their response or adverse reaction to
medicines or xenobiotics.
Stemnovate has diverse bank of IPS lines that represent the human variability for pharmacogenetics studies.

Reduces Animal Testing Veterinary Research and Development

Our multispecies cellular models allow in vitro studies for mechanism of action, transporters and signalling pathways. This reduced animal testing while the models benefit veterinary drug development and disease modelling.

Drug metabolism Cytochrome P450 studies

Cytochromes P450 (CYPs) are the main enzymes involved in drug metabolism. These show huge expression variability among humans. We study CYP inhibition, induction, expression and polymorphism.

Multicellular Modelling Tissue engineering

Tissue consists of specialised cells functioning while uniquely organised. We simulate this organisation for microphysiological studies. Eg, Liver tissue consists of hepatocytes, stellate and Kupffer cells.

ANIMAL WELFARE
iPSCs represent an extremely valuable tool for modelling disease and organ toxicity, with enormous potential in veterinary medicine. Several animal diseases are currently untreatable and can result in euthanasia on medical grounds. In contrast to humans, in vitro models for cellular research in animals do not exist. Therefore it has been necessary to explore the use of stem cells in constructing cell based models. Teratoma studies are conducted to evaluate the differentiation potential of stem cell lines (both embryonic as well as induced pluripotent stem cells). This technique is both indirect, time consuming costly and painful for the animals. At stemnovate we have proven protocols that involve spontaneous, directed differentiation with 3D tissue engineering and organotypic culture techniques. The in-depth analysis provides morphological evaluation, protein and comprehensive genetic expression data to replace the teratoma studies.
COMPLIANCE

Stemnovate is a compliant organisation and all the procedures meet regulatory requirements.

Human Tissue Authority (HTA)
Stemnovate human cell slourcing is in compliance with the HTA, License since 2018. HTA is a regulatory body in the UK that regulates organisations that remove, store and use human tissue for research, medical treatment, post-mortem examination, education and training.

The Health and Safety Executive is a UK government agency responsible for the encouragement, regulation and enforcement of workplace health, safety and welfare, and for research into occupational risks in Great Britain. Stemnovate operations are compliant for Class-2 contained use (Genetically modified organisms (contained use) regulations 2014.

IPS technology license
Stemnovate obtained commercial license for IPS technology in 2018

Our clients say

You are doing some amazing and important work at Stemnovate, we are happy to be associated with your project.

Volunteer
Volunteer for blood donation for liver research

Thank you for your presentations, they were really great and stimulating. I am very happy we met and that we could get the cells in culture!

Academic Institution
University of Bern

CASE STUDIES

Partnering for Smart engineering

Prof Ciro Semprebon will be working in partnership with Stemnovate on the prestigious EPSRC grant project for advancing SLIPS technology.

25.10.2019
Partnering for SciSpacE Microgravity Application Promotion Programme

Stemnovate has partnered with multinational collaborators on a project coordinated by MEDES Institute of space medicine and physiology. 

25.10.2019