Stemnovate Next-Gen Platforms
Drug Discovery Platform
Bio Banking
Molecular & Microengineering
Data Platform
Partnerships
Live Campaign
Why Volunteer for Alpers- Huttenlocher Syndrome: a rare mitochondrial disease in children?
Stemnovate is working on a platform to treat rare diseases in children, especially mitochondrial diseases that severely impact the liver, heart and brain functions.
HOW IT WORKS
In vitro Absorption, distribution, metabolism and excretion studies can be conducted on tissues showing multicellular interactions in microphysiological systems.
The multiparametric data obtained from cell studies, assays, protein and gene expression and imaging is used for data analysis and predictive modelling of drug response.
The quantitative data is obtained through biosensors for microenvironment changes and physiological parameter analysis.
Cytochrome P450 studies are complimented with metabolism assays, expression profiling and transcriptomic analysis. A comprehensive data to understand the mechanistic of action or toxicity.
In-depth studies for cell proliferation, apoptosis, receptors & transporters.
Microfluidic device development involves CAD design, 3D printing, prototyping following by application optimisation and manufacturing.
Pharmacogenetics allows the study of the genetic variation due to ethnicity and gender that affects their response or adverse reaction to
medicines or xenobiotics.
Stemnovate has diverse bank of IPS lines that represent the human variability for pharmacogenetics studies.
Our multispecies cellular models allow in vitro studies for mechanism of action, transporters and signalling pathways. This reduced animal testing while the models benefit veterinary drug development and disease modelling.
Cytochromes P450 (CYPs) are the main enzymes involved in drug metabolism. These show huge expression variability among humans. We study CYP inhibition, induction, expression and polymorphism.
Tissue consists of specialised cells functioning while uniquely organised. We simulate this organisation for microphysiological studies. Eg, Liver tissue consists of hepatocytes, stellate and Kupffer cells.
