Stemnovate Next-Gen Platforms
Drug Discovery Platform
We use novel multi-organ modelling to evaluate drug molecule metabolism and toxicity, ensuring better clinical trials and patient safety outcomes. Our projects include Hepatitis research and many more.
Our work on automation for cell based assays save cost and time and revolutionize the pharmaceutical industry.
Bio Banking
Ethical sourcing is core to our biobank, reflecting human diversity in age, gender & ethnicities. We are experts in cellular reprogramming with the capability for human and animal reprogramming.
For industry and academia, we routinely differentiate stem cells into the liver, heart, and neuronal cells.
Molecular & Microengineering
We design vectors with an industrial process to generate induced pluripotent stem cell In addition, we offer a multispecies cell platform ensuring quality through advanced profiling and bioinformatics.
We provide digital karyotyping and genotyping for disease profiling and understanding drug metabolism response.
Data Platform
The drug discovery data often cannot be reproduced with conventional techniques. Therefore, we integrate computational modelling and microengineering to enable next-gen drug development.
Stemnovate aims to make precision medicine a global reality through unique data platforms and novel devices.
Partnerships
Our global partnerships include top-tier pharmaceutical companies and world-renowned academia. We often partner with institutes for industrial PhD studentships, such as the
National Physical Laboratory, the University of Edinburgh, the University of Northumbria, and the Babraham Institute, to name a few.
Featured Blog
TALE OF TWIN CITIES: CAMBRIDGE FOR STEM CELL RESEARCH
Cambridge has an excellent ecosystem for biotech, espaicially working in the stem cell research space to thrive.
Please read our latest blog and be part of community.
HOW IT WORKS
In vitro Absorption, distribution, metabolism and excretion studies can be conducted on tissues showing multicellular interactions in microphysiological systems.
The multiparametric data obtained from cell studies, assays, protein and gene expression and imaging is used for data analysis and predictive modelling of drug response.
The quantitative data is obtained through biosensors for microenvironment changes and physiological parameter analysis.
Cytochrome P450 studies are complimented with metabolism assays, expression profiling and transcriptomic analysis. A comprehensive data to understand the mechanistic of action or toxicity.
In-depth studies for cell proliferation, apoptosis, receptors & transporters.
Microfluidic device development involves CAD design, 3D printing, prototyping following by application optimisation and manufacturing.
Pharmacogenetics allows the study of the genetic variation due to ethnicity and gender that affects their response or adverse reaction to
medicines or xenobiotics.
Stemnovate has diverse bank of IPS lines that represent the human variability for pharmacogenetics studies.
Our multispecies cellular models allow in vitro studies for mechanism of action, transporters and signalling pathways. This reduced animal testing while the models benefit veterinary drug development and disease modelling.
Cytochromes P450 (CYPs) are the main enzymes involved in drug metabolism. These show huge expression variability among humans. We study CYP inhibition, induction, expression and polymorphism.
Tissue consists of specialised cells functioning while uniquely organised. We simulate this organisation for microphysiological studies. Eg, Liver tissue consists of hepatocytes, stellate and Kupffer cells.
