Stemnovate's pioneering platform is revolutionizing drug discovery and disease modelling with its innovative 'one medicine' concept. This is the future of healthcare innovation, offering unparalleled features.

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Applications
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DNA synthesis has the potential to revolutionise the fields of drug discovery, biotechnology, nanotechnology and oligonucleotide synthesis.
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Drug Discovery
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The applications are varied, including RNA therapy, antibody research and vaccine development.
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Biotechnology
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DNA synthesis helps facilitate drug bio-production, biofuel research, crop production and research for food security.
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Nanotechnology
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DNA synthesis is being explored for novel DNA data storage and nano-material discoveries.&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;
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<div class="ps-section__desc mx-2" style="text-align: center;">Platform Features</div>
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Stemnovate is soon introducing a microfluidic platform for DNA synthesis. This disruptive technology allows template-free DNA/RNA synthesis that can potentially accelerate the development of new therapeutics in the pharmaceutical sector, e.g. antibody research, drug bio-production and RNAi based therapeutics. This microfluidic platform technology overcomes the current limitations of DNA synthetic technology.

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Predictive modeling plays a pivotal role in the development of personalized therapies, drug repurposing, and drug discovery. By integrating diverse data types, including imaging, cell and tissue engineering, and transcriptomics, researchers can gain a holistic understanding of biological systems and discover new drugs cost effectively.

We are revolutionizing drug discovery to make it faster, safer, and more cost-effective, with a patient-centred approach at the core of our mission.

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Stemnovate integrates stem cell research, molecular science, and tissue engineering to develop disease models. We maintain a unique biobank of cells and stem cells that reflects human diversity. Our patient cells are sourced in accordance with compliance, ethical standards, and informed consent. We study diseases in vitro, conducting in-depth genetic analyses and employing tissue engineering to recreate and examine cell physiology in the laboratory, along with assays for multiparametric analysis.

Stemnovate's unique, patient-centric approach is revolutionizing disease modeling with its innovative technology platforms.

We are revolutionizing drug discovery to make it faster, safer, and more cost-effective, with a patient-centered approach at the core of our mission.
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Currently, fewer than one in 10,000 potential drug compounds successfully makes it to clinical use, underscoring the complexity of the drug discovery process. We are dedicated to changing this outcome.

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Stemnovate&rsquo;s breed identification platform highlights
1. Microsatellite and SNP profiling of cell line. 2. Breed identification and percentage composition at a high accuracy.
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FAQ BREED IDENTIFICATION
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What is a Microsatellite and Single Nucleotide polymorphism (SNP)?
Microsatellites or Short tandem repeats (STRs) are DNA sequences that have a repetitive unit of 1-6base pairs which forms lengths of up to 150 nucleotides. Single nucleotide polymorphism (SNPs) is a genomic variant at a single base position in the DNA. SNPs are biological markers that can be used to locate genes. STRs and SNPs are widely spread throughout the genome and are located in the coding and noncoding regions of DNA. They vary slightly among chromosomes e.g. in humans, chromosome 19 has the highest density of STRs. STRs play an important role in forensic science, evolutionary biology, population genetics, QLT mapping, evolutionary genetic and pathogenesis.
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2.Why is breed identification important?
Breed identification can be used to assess breeding history and breed purity of specific animal breeds. It also helps in safeguarding the rights of consumers and producers to prevent the sale and consumption of adulterated products (Dalvit et al., 2007; Sentandreu &amp;amp; Sentandreu, 2014). It also helps with the traceability and conservation efforts of target breeds of interest.
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3. How does it work?
High molecular weight DNA is isolated from the cell line and the genomic DNA (gDNA) is enzymatically digested and tagged with sequencing adaptors on the 5&rsquo; phosphate end and 3&rsquo; hydroxyl group end of the gDNA. &nbsp;Barcoded adapter tagged gDNAs are then transferred to a flowcell for accurate long read sequencing and basecalling. Nucleotide raw reads which can&nbsp;be in either a FASTQ, FASTA or BAM format are computationally assembled and analysed for&nbsp;STR and SNP markers. Detected biomarker polynucleotide regions are ascribed to reference genome database of target breeds at a high accuracy and confidence level.
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4. How long does it take to obtain a result?
Turnaround time (TAT) is 6-8 working days

Stemnovate has recently introduced a new service for businesses and researchers working in animal health. This service offers advanced breed identification and bioinformatics to determine breed and gender accurately. Our breed identification service can provide the answers you need to comprehend species' and animal breeds' unique characteristics. Improved understanding can lead to better treatment for your furry friend. Take advantage of this opportunity to learn more - contact us today!

Digital Karyotyping-Animal species DNA Testing

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The primary focus of technology is obtaining detailed information on chromosomal structural variance (SVs) to identify genomic abnormalities, including deletion, insertion, duplication, and inversion events, without any bias.
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Frequently Asked Questions (FAQ) about Animal-Based Digital Karyotyping:
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1.&nbsp;What is the animal digital karyotyping platform?
For animal cell line analysis, Stemnovate uses a digital karyotyping tool that screens and identifies structural chromosomal variations such as deletion, duplication, insertion, and translocation changes at the genome level. This platform provides unprecedented access to crucial genetic information for studying cell line stability in cultures, animal diseases and modelling.
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2.&nbsp;Why is karyotyping important?
Karyotyping detects the chromosomal integrity of cell lines. It's crucial as culturing can compromise it. Factors like cultural media composition conditions can affect cells. It is valuable for identifying animal diseases and structural variations in the animal genome that have applications in animal health drug discovery and breeding.
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3. How does it work?
We culture cells and isolate DNA from cell lines subjected to sequencing, followed by bioinformatic analysis to detect changes in the genetic makeup.
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4. What animal species can be analysed?
We analyse pigs, cats, dogs, horses, chickens, mice, cows, Sheep and C.elegans and zebrafish.&nbsp;Stemnovate is expanding its animal-based platform to include a broader collection of other animal species.
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5. What is required for the animal digital karyotyping test?
We typically require 1 million cells in a frozen pellet format. We can also culture cells if repeat analysis is required to study batch stability and variations.
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6. How long does it take to obtain a result?
The turnaround time is 9-11 working days. It can be customised to meet specific requirements.

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Stemnovate has launched a digital Karyotyping service for researchers and businesses in the animal health sector and emerging new technologies such as cultured meat. The platform provides crucial information concerning the genomic integrity of cultured animal cell lines, including primary cells, stem cells, and differentiated cell types.&nbsp;

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The resulting pain and inflammation in a pet's mouth can hinder their ability to eat or drink, and the bacteria can enter their bloodstream, causing damage to their kidneys and other vital organs. This underscores the critical need for proactive oral health care for your pet.
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Cats and dogs clean their teeth in the wild by chewing on bones or grass, but domestic pets often lack suitable alternatives. Owners may find it challenging to check their pets' oral health, so we are introducing the most advanced technology to help ensure the oral health of beloved pets. Our advanced technology equip veterinarians and owners to know about the microbes affecting pets. 
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The DEN-OR-KIT is not just a kit; it's a game-changer for your pet's oral health. This user-friendly at-home kit offers a comprehensive and accurate analysis of the microbes in your pet's mouth, allowing you to assess their oral and dental health.
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It utilizes advanced DNA sequencing technology and bioinformatic analysis to rapidly profile the oral microbiome. Our cutting-edge analysis method provides a thorough, unbiased test. It covers a broader range of microbes than the quantitative PCR method. Our next-generation sequencing (NGS) approach will comprehensively identify and report the microbes in the provided samples, giving you the power to take control of your pet's oral health.

Left unchecked, pets can develop harmful bacteria, debris, and plaque on their teeth from their food. Over time, this can solidify into tartar, leading to gum irritation, gingivitis, and tooth loss.

IN 2020 IN GREAT BRITAIN, 2.88 MILLION PROCEDURES INVOLVED LIVING ANIMALS.&nbsp;But over half, 53% of experimental testing, was for basic research focusing on the immune system, nervous system and cancers.

Pioneering Animal Stem Cell Technology.
We are creating first in class models for dogs, cats, cows, horses and pigs.
Animal research has been an essential contributor to improved human health. We owe several vaccinations and understanding of diseases and treatments to animal sacrifices. But there is an urgent need to reconsider and reduce animal testing.

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Reduction
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By providing animal cell and tissue-engineered models of wound healing and skin testing we are reducing animal testing.
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Replacement
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By providing tissue models on a chip, we are replacing animal testing.
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Refinement
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By providing ethically sourced cells, we offer an alternative to animal testing.
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What is Cellular Reprogramming and Differentiation?
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Induced pluripotent stem cells (iPSc) are created in the lab by reprogramming cells from the skin. The IPSCs paved the way for creating several cell types in the laboratory and have massive potential for disease modelling and drug discovery. For humans, IPS cells have potential uses for spinal cord injuries, Alzheimer&rsquo;s, etc. Similarly, IPSCs have the potential for veterinary research and reducing animal testing. This technology can help create novel treatments for animals where traditional methodologies are inadequate, such as wound healing, complex fractures, spinal cord injuries, cancer, diabetes and many more.
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FAQ
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How can I help?
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Stem cell research and &lsquo;organ on chip technology&rsquo; requires animal cells. Tissue donation can help accelerate our research work.
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Which tissues can be donated?
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We need different tissue samples for our research. Tissue usually discarded after routine surgeries such as spaying or neutering, or other surgeries can be donated to support our work.
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What can I do to donate?
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Pl. Fill in the consent form provided for tissue donation.
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How will the tissue sample be used?
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The tissue samples collected will be used for nucleic acid (DNA, RNA) extraction to understand the genetic variability and diseases in different animals. The commercial use includes cell lines, assays and tissue engineering.
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What are the benefits?
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The cells assay, cell lines and tissue-engineered models for commercial use such as new drug discovery, disease modelling and in the future maybe cell therapies. 1) Disease modelling for cancer, injuries, arthritis, diabetes etc. 2) Animal welfare (reduction, replacement and refinement of animal use in research)
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Will the owner's information be required?
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It is an anonymous donation, so the only information required is information about the animal's breed, age, gender and confirmation that the animal is vaccinated and free from any infectious diseases.
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How will it reduce animal testing?
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Cells usually discarded after surgery can instead be used by Stemnovate to develop cell&nbsp;lines. This ethical sourcing can help reduce animal sacrifices.
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I want to get involved and know more.
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Our team comprises of renowned scientists, veterinarians and clinicians&nbsp;with affiliations to top institutes in the UK.

Stemnovate Limited in Cambridge provides novel&nbsp;&lsquo;organ-on-chip&rsquo; technology. This technology promotes 3Rs,&nbsp;replacement, refinement and reduction of animal testing.

At Stemnovate, we are dedicated to transforming animal health through innovative genetics and a pioneering technology platform. Our strict no-animal-testing policy guarantees a brighter future for animal-friendly research.

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