<div>&nbsp;</div>
<div>What sets Stemnovate apart is our commitment to next-generation cell line authentication and to supporting researchers. We uniquely combine NGS-STR profiling with custom data services, delivering unparalleled accuracy and traceability for every cell line we provide. Our subscription package ensures researchers have continuous access to expert support and quality assurance, not just at the point of purchase but throughout the entire research lifecycle. This integrated approach is at the forefront of cell line validation, empowering researchers with confidence in the authenticity and reproducibility of their results.</div>
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<div>STR (Short Tandem Repeat) profiling</div>
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<div>Short tandem repeat (STR) profiling is the gold standard for human cell line authentication. It ensures reproducibility by verifying cell identity and detecting cross-contamination.&nbsp;</div>
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<div>STR with Next-Generation Sequencing&nbsp;is an advanced alternative to traditional capillary electrophoresis (CE) for cell line authentication. It offers greater sensitivity for detecting cross-contamination and provides complete sequence information for repeat motifs, which size-based analysis cannot achieve.</div>
<ul>
<li>Superior Sensitivity:&nbsp;STR-NGS detects minor cell line contaminants at ratios as low as&nbsp;1:200 (0.5%), while conventional CE typically detects mixtures only at 1:5 or 1:10 (10&ndash;20%).</li>
<li>Sequence-Level Resolution:&nbsp;Unlike CE, which measures only fragment length, sequencing identifies single-nucleotide polymorphisms (SNPs) and internal sequence variations within STR repeats.</li>
<li>Advanced characterisation at Stemnovate delivers comprehensive&nbsp;information on cell line origin, genotyping accuracy (85%-100%), and isoallele resolution to confirm sample identity. In comparison to conventional approaches, this level of detail ensures greater certainty in cell line identification and significantly enhances the reliability of research outcomes.</li>
</ul>

Primary cells and immortalised or continuous cell lines are essential for basic and preclinical research. However, misidentified cell lines pose a significant risk to scientific reproducibility(Soren et al., 2022). The HeLa cell case illustrates these consequences. Derived from Henrietta Lacks in the 1950s, HeLa cells spread rapidly across laboratories, but a lack of authentication compromised research results.

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The potential to grow and maintain any cell type of interest has excellent clinical value, creating the opportunity to develop a scalable and functional cell source for ex vivo cell therapy development, and explore novel therapeutic modalities.
Unfortunately, generating induced pluripotent stem cells can often be a costly and time-consuming process.
Stemnovate offers custom reprogramming services, saving you the time which can be better spent performing valuable research experiments.
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<h2 class="p-1 text-center font-weight-bold">More Information</h2>
Cellular reprogramming involves transient expression of inducible genes to generate stable lines. The stable IPSC lines are selected through stringent pluripotency characterisation and the ability of cells to differentiate into derivatives of three germ layers.
Cell fates during development are neither restrictive nor irreversible. Pluripotent cells can form all somatic lineages.
Cellular reprogramming has multiple applications: we can now convert a patient's blood cells to study any organ's disease process; cellular reprogramming could also be used to evaluate the efficacy and safety of newly developed drugs on human patient cells, or test drugs that might have side effects in only a small subpopulation of patients in a personalised manner before administration.
Stemnovate has a commercial license for IPS technology, and with that, we have molecular design and analysis capability for efficient reprogramming.

We provide the best human cell models for drug discovery and disease modelling using cellular reprogramming. The ethical method uses adult skin or blood cells donated by volunteers and is core to our biobank, reflecting human diversity in age, gender, and ethnicity.
Cellular reprogramming unleashes endless possibilities within drug development and research. It directs cellular identity to produce a therapeutically valuable cell type.

All cells are derived from stem cells and obtain their functions as they mature. Cell differentiation is how progenitor cells change their functional or phenotypical type.
Interestingly, the differentiation process alters the cell's shape, size, and energy requirements.
We use mechanical and chemical stimuli to direct IPSC to the liver, heart, neurons, bone and muscle cells, to name a few.
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<h2 class="p-1 text-center font-weight-bold">More Information</h2>
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Our differentiation processes are guided by several years of research, in-depth understanding of principles of development, advanced gene and protein expression studies along with novel methods of microengineering and computational data analysis.
 
Stemnovate has established protocols that have higher efficiency of differentiation as well as reproducibility. This saves effort reinventing the wheel and ensures efficiency for the application development.
 
You can request a quote to learn more about our application development.
</div>

Cell differentiation is known as a process in which cells become specialized. Stem cells have the potential to become any cell type at the beginning, but this capability is slowly lost as the cell differentiates and gains unique functions.&nbsp;

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Whole transcriptomics
RNA-seq is a powerful tool that can be utilized to analyze and provide an unbiased transcriptome profile. This tool ultimately empowers researchers with the ability to determine cellular functionality and gene expression during or after an experimental study. Stemnovates WTS features;
<ol>
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1. Exome analysis for nucleotide sequence capture and quantitative gene expression.
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2. Metatranscriptomics study for species identification and taxonomic classification and microbe quantification.
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3. Discovery of novel Biomarkers inferred from in-depth bioinformatic analysis and computational modeling.
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4. Chromosomal -loci gene expression report and human gender identification.
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</ol>
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<h2 class="p-1 font-weight-bold">Bioinformatics</h2>
Stemnovate's Bioinformatic platform provides a robust computational analysis of biological data. Stemnovate harnesses an interdisciplinary approach integrating biological data sets with advanced mathematical analysis and computational science to capture and interpret complex data. Our platform is already being used by industry and academia for new drug discovery and understanding diseases of the heart, liver and sensory systems in the body. Some bioinformatic workflow include :
<ol>
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1. Computational modeling for co-expression and fusion -fission events.
</li>
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2. Gene signaling network.
</li>
<li>
3. Protein-protein interaction network
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<li>
4. Phylogenetic profile occurrence.
</li>
</ol>
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<h2 class="p-1 text-center font-weight-bold">Genotyping</h2>
The genotype is the genetic makeup of a cell, organism or individual with reference to a particular characteristic. The DNA variants are shown to modulate protein function, and hence drug response, through multiple mechanisms. Genetic polymorphism for cytochrome 450 (P450) enzymes leads to interindividual variability in the plasma concentrations of many drugs. In some cases, P450 genotype results in decreased enzyme activity and an increased risk for adverse drug effects. In other cases, P450 genotype may influence the dose of a drug required to achieve a desired effect.
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<h3 class=" font-weight-bold">How Genotyping influences Drug Discovery?</h3>
Human population reveals differences in drug metabolism and response. <a class="reference-website" href="https://pubmed.ncbi.nlm.nih.gov/14618296/" target="_blank" rel="noopener noreferrer">The poor metabolizers with absent cytochrome P450CYP2D6 are found in 5&ndash;10% of European and African populations, but are less common in Asian subjects.</a>

Stemnovate provides whole genome transcriptomics as a service. This invaluable tool provides an unprecedented coverage and depth into the transcriptional regulation of cells. The platform utilises high accuracy for both long and short reads. We provide bioinformatics to reveal gene signalling networks and novel transcript signalling pathways.

Our unique platform operates with highly efficient, data-driven processes. These processes, which utilize high-resolution images, genomic profiles, biological data, and molecular and metabolite profiles, are designed to significantly benefit your drug discovery and toxicology research. By correlating, assimilating, and connecting this data at a rapid pace, we aid in discovering patterns, thereby accelerating your study and increasing the likelihood of successful outcomes.
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Our ambition to automate toxicity prediction is not just a technological advancement. It's a potential game-changer for precision drug discovery, with the power to revolutionize the industry and make precision medicine a reality.
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Platform Features
Stemnovate is a leader in the field, with a team of experts who are not just capable, but also passionate about designing experiments and microengineering bespoke solutions to enhance the repeatability of complex cell cultures. Our team's expertise ensures that your research is in the best hands. Once a methodology is optimized, the process can be set for reproducibility and automation.
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Our platform is dedicated to supporting projects in achieving a higher standard of accuracy. We do this by evaluating biocompatibility and tolerance, ensuring that your research is of the highest quality.
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Stemnovate In Vitro Toxicology 
Stemnovate's in vitro toxicology assays utilize primary cells or induced pluripotent stem cell-derived cells, such as heart, liver, and neuronal cells, in controlled laboratory conditions to assess the toxic properties of compounds and mixtures. These assays provide accurate results and eliminate the need for animal testing, aligning with ethical research practices.
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We develop assays to examine the toxicity of xenobiotics at the cellular level, replacing animal testing, which often fails to represent human physiological responses due to species differences accurately.
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Quality Control&nbsp;&nbsp;
We provide various quality tests to evaluate the quality of cell products. These tests employ advanced bioinformatics along with gene and protein expression analysis. Our quality control measures include testing for:
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- Mycoplasma
- Human viruses (HIV-1, HIV-2, HBV, HCV)
- Animal species-specific viruses
- Mycobacterium

Stemnovate in vitro testing platform simulates the liver, heart and neuronal cell response to evaluate predictable and unpredictable toxins over the breadth of the genetically diverse human population.&nbsp;

It is well known that stem cell culture over a long time can result in genetic instability. For your research to move forward confidently, you must be able to monitor your cell culture for genomic integrity quickly and continuously.

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The human population has four races,&nbsp;white/Caucasian, Mongoloid/Asian, Negroid/Black, and Australoid. There is not only a difference in hair and skin but also interindividual variability in drug metabolism. The Cytochrome P450 (P450) enzymes primarily contribute to these differences. There are several gene variants but the primary genes included in drug labelling are limited to&nbsp;CYP2C9,&nbsp;CYP2C19, and&nbsp;CYP2D6.
The CYP2D6 enzyme metabolises about 25% of clinically used drugs, including anti-depressants, antipsychotics, antihypertensives, and analgesics.&nbsp;
Stemnovate provides genotype studies for CYP1A1, CYP2D6 and CYP3A4.
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<a href="https://youtu.be/uQ1Vz8QgfQs?si=HVf26hbaXx6BXpGW" target="_blank" rel="noopener">Discover our genotyping by clicking the link below. Don&rsquo;t forget to subscribe to our channel and connect with us on social media for the latest updates and insights.</a>

A genotyping analysis attempts to untangle the complex relationships between genotypes and phenotypes.

<h2 class="p-1 text-white font-weight-bold">&nbsp;</h2>
<div class="ps-section__desc mx-2">
Compliant &amp; Ethical Biobanking
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When you request sourcing from Stemnovate, you can be confident that our process is simple, compliant, and ethical. We strictly adhere to the guidelines set by the Human Tissue Authority in the United Kingdom, ensuring that our operations meet the highest standards of ethical practice.
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At Stemnovate, we prioritize compliance and source cells only from living donors who provide full informed consent. This approach guarantees the ethical integrity of our biobank and offers donors a meaningful opportunity to contribute to scientific research. Ethical considerations in biobanking are paramount to us, and we are dedicated to maintaining a high-quality, ethical biobank. Our commitment to these standards ensures you can trust our services' quality and moral nature.
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Explore Our Biobank
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Our inventory includes a variety of induced pluripotent stem cells, each characterized by unique features such as pluripotency, stability, karyotype, and genotype. These cells can differentiate into any cell type in the body, making them a valuable resource for various research applications.
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Induced Pluripotent Stem Cells
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Multispecies Biobanking
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Our commitment to reducing animal testing is unwavering. In addition to human cells, we have a multispecies biobank for animal cells. We collaborate with veterinarians to ensure the ethical sourcing of animal cells, which pet owners donate during routine surgeries. This process, under the guidance of a veterinarian and a proper tissue donation process, ensures that our processes harm no animals. We have also developed in vitro models to replace and refine animal testing, demonstrating our dedication to ethical practices.
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Check Out Our Multispecies Biobank
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<a style="color: rgb(53, 152, 219);" href="https://stemnovate.co.uk/Products/Biobanking/Primary-Cells-Animal">Primary Animal cells</a>
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We offer custom sourcing through a user-friendly online process. 
Fill in your requirements and our team will contact you.
<h2 class="text-white">&nbsp;</h2>
<h2 class="text-white"><a style="color: rgb(53, 152, 219);" title="https://share.hsforms.com/12uKLLajnT52galA2Nooq-g38yge" href="https://share.hsforms.com/12uKLLajnT52galA2Nooq-g38yge">Bio-sourcing Request Form</a></h2>
&nbsp;
<h5><a href="https://youtu.be/QElNtGz6kQM?si=r6AmTHai2OalRNaa" target="_blank" rel="noopener">Discover our Biobank by clicking the link below. Don&rsquo;t forget to subscribe to our channel and connect with us on social media for the latest updates and insights.</a></h5>
</div>

Stemnovate Biobank stands out with its diverse collection of human cells, encompassing both genders and a wide range of ethnicities. Not only are we recognized for providing high-quality cells, but our research and development technology can also help save time and costs, ensuring successful outcomes. Furthermore, our collaborations with top-tier pharmaceutical companies and the world's leading research institutes enable the acceleration of new technology and applications.

&nbsp;
Predictive modeling plays a pivotal role in the development of personalized therapies, drug repurposing, and drug discovery. By integrating diverse data types, including imaging, cell and tissue engineering, and transcriptomics, researchers can gain a holistic understanding of biological systems and discover new drugs cost effectively.
<a href="https://youtu.be/2hO7-VOXmBE?si=LL5-JtYYwXA89tyF">Discover our next-generation drug discovery by clicking the link below. Don&rsquo;t forget to subscribe to our channel and connect with us on social media for the latest updates and insights.</a>

We are revolutionizing drug discovery to make it faster, safer, and more cost-effective, with a patient-centred approach at the core of our mission.

Drug Discovery Platform

Platform Services

STR-cell authentication

Cell Reprogramming

Cellular Differentiation

Molecular Analysis

In-vitro toxicology

Karyotyping

Genotyping

Biobanking